Archieve Issue

Background: While earlier research from different parts of the world suggested that COVID-19 vaccination does not increase the risk of death, these studies may have been influenced by certain hidden biases. To explore this further in a more reliable way, a modified version of the Self-Controlled Case Series (SCCS) method was used to study whether COVID-19 vaccines cause any increased risk of death not related to COVID-19 infection, overall mortality, or specific heart-related deaths. This study aims to clarify these risks after completing the full initial vaccine course (primary series). Methods: In this study, researchers examined data on all deaths that occurred between 14 December 2020 and 11 August 2021 across eight medical data networks in India. Death records of people who received COVID-19 vaccines were compared with those who remained unvaccinated. The analysis considered different vaccine types — Pfizer-BioNTech (BNT162b2), Moderna (mRNA-1273), and Johnson & Johnson (Janssen, Ad26.COV2.S) — and examined how often death occurred in the 14 and 28 days following vaccination (risk periods). This timeframe is important because most adverse effects, if any, are expected to happen shortly after vaccination. To avoid seasonal biases (for example, higher death rates in winter months), data from unvaccinated individuals were included in the analysis to help adjust for calendar month trends. Key Findings : Pfizer-BioNTech Vaccine (BNT162b2): Across both doses and both timeframes (14 and 28 days), the risk of death from any cause, non-COVID-related causes, or cardiac conditions was lower than expected. The confidence intervals were statistically significant, meaning the findings are unlikely due to chance. Moderna Vaccine (mRNA-1273): The estimated risk of death was also lower overall. However, for a few specific outcomes (especially heart-related deaths after the second dose), the statistical confidence intervals included 1 — suggesting no significant increase or decrease in risk, particularly in individuals without prior cancer or heart disease. Janssen Vaccine (Ad26.COV2.S): For this single-dose vaccine, the risk of heart-related deaths was similar to or slightly below expected levels, but the confidence intervals also included 1 — again indicating no significant increase in risk. Conclusion: This study, using a robust analytical method, provides strong evidence that COVID-19 vaccination does not increase the risk of death — whether from general causes or heart-related issues. This holds true for all three major vaccines studied in the U.S. These findings align with data from India as well, where millions have received Covishield (AstraZeneca), Covaxin (Bharat Biotech), and other vaccines. Although different vaccines were used, similar surveillance methods by the Ministry of Health & Family Welfare (MoHFW), Government of India, and reports from the National Adverse Event Following Immunisation (AEFI) committee also found no causal link between COVID-19 vaccines and increased mortality. The study further reinforces public confidence in vaccination as a safe and essential public health measure — especially during and after the pandemic.

This case report highlights the challenges of psychotropic polypharmacy in a 36 year old f emale patient with chronic Paranoid Schizophrenia and co morbid Type 2 Diabetes Mellitus and Hypothyroidism. To manage her acute psychotic symptoms, she was placed on a complex regimen including Clozapine, Aripiprazole, and adjuvants. During hospitalizatio n, the patient experienced two distinct, significant Adverse Drug Reactions (ADRs) related to central nervous system (CNS) depression: Excessive Sedation attributed to Clonazepam (a benzodiazepine) and a subsequent episode of Sedation linked to Maxgalin (l ikely Gabapentin). These events underscore the heightened risk of cumulative sedative effects when combining medications in complex psychiatric cases. Prompt recognition and de prescribing of the suspected agents were essential for mitigating patient morbi dity, preventing non adherence, and ultimately facilitating functional recovery. This case emphasizes the critical role of vigilant pharmacovigilance in balancing therapeutic efficacy with drug safety for achieving long term stability in chronic schizophre nia management.

Since milk contains nearly every ingredient required for a person to consume food on a regular basis, it is a complete food. In particular, cow milk is consumed globally more often than the milk from other mammals. Cow milk's properties include Madhura (sweet), Sheeta (cool), Mrudu (soft), Snigdha (unctuous), Bahala (thick), Shlakshna (smooth), Picchila (sliminess), Guru (heavy), Manda (dull), and Prasanna (inspires enthusiasm). It also possesses the traits of Jeevaniya (vitalizer) and Rasayana (rejuvenate). Samskara is a method that involves boiling, cleaning, storage in various vessels, and other procedures to generate changes in the qualities of any substance. These Samsakara may enhance the substance's quality or degrade it. The purpose of this review article is to highlight the importance of utilizing the proper metal utensil and milk boiling technique, as well as the application of this knowledge in the prevention of metal contamination and milk-borne illnesses. A comprehensive literature search was conducted using Ayurveda texts and databases like Google Scholar, SCOPUS, and PubMed, focusing on keywords related to heavy metals, milk, and heat. Studies assessing heavy metals in cow milk, the effects of heat on milk proteins, and contamination through unprocessed milk were included, while studies on other species' milk, non-English articles, and abstracts were excluded. Data were extracted and synthesized using a narrative and quantitative approach to highlight trends and gaps. This review supports the facts about boiling and storing milk. Milk should be boiled in Earthen pot/ Clay vessels or in non-reactive metal vessels like stainless steel. Boiled milk should be stored in an Earthen or Wooden vessel.

This study explores the phytochemical composition, physicochemical properties, and gastroprotective potential of a hydro-alcoholic extract of Terminalia catappa (HATC) in leaf and bark parts, with particular emphasis on its formulated herbal syrup (HATCHS). The extract yield was 10.7% w/w, with dark brown semi-liquid characteristics. Phytochemical screening confirmed the presence of several bioactive compounds, including alkaloids, phenols, flavonoids, tannins, and glycosides. Pharmacological evaluations, including ulcer index, pH of gastric contents, total acidity, gastric volume, antioxidant parameters (SOD, CAT, GSH), and histopathological analysis were performed. Results indicate significant gastroprotective and antioxidant effects, especially with higher doses and syrup formulation, showing near comparable efficacy to standard omeprazole treatment.

Kaphaja Artava Vikriti, correlating with Polycystic Ovary Syndrome (PCOS), is among the most prevalent endocrine–metabolic conditions in women of reproductive age. Ayurveda offers a comprehensive and individualized framework for its management. In this report, a 29-year-old woman presented with oligomenorrhea. Pelvic ultrasonography revealed bilateral polycystic ovarian morphology. Intervention: The treatment strategy combined Sodhana through virechana with subsequent Shamana measures. Additionally, lifestyle modification—Kapha-reducing diet, structured exercise, and yoga–meditation—was emphasized. Outcomes: Within 6 months, the patient experienced restoration of regular 28-day menstrual cycles, weight loss of approximately 7 kg, and sonographic regression of ovarian cysts. Conclusion: This case highlights the effectiveness of a holistic Ayurvedic protocol integrating Sodhana, herbal remedies, and lifestyle modification in the management of artava vikriti , leading to both symptomatic relief and measurable clinical improvement.

Ayurveda emphasizes that Ahara (diet) is the foremost pillar of life and health. The concept of Samskara Kalpana (dietary processing and modifications) highlights the role of transformation in enhancing utility, digestibility, safety, and palatability of food. The objective of this review is to critically analyze various Samskara (processing methods) described in classical texts with special reference to their relevance in present-day nutrition. Materials and Methods include textual review of Brihattrayi, Laghutrayi, commentaries, and modern nutritional literature. Observations reveal that Samskara improves bioavailability, reduces toxicity, and ensures preservation. It also modifies guna (qualities) and karma (functions) of Ahara dravya. Conclusion: The principles of Samskara Kalpana retain significant value in preventive and clinical nutrition and can guide the modern food processing industry.