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Groundwater contamination, particularly from geogenic sources, has become an increasingly pressing issue, exacerbated by the limited availability of clean water resources and the widespread pollution affecting these resources. This study focuses on the assessment of geogenic contamination of groundwater in Bikaner city, Rajasthan, highlighting the impact of both natural and anthropogenic factors on water quality. Groundwater, a crucial resource historically used for various purposes, has deteriorated due to excessive use of chemicals and pollutants. Natural processes such as the leaching of contaminants from geological formations and brine intrusion contribute significantly to groundwater contamination. Additionally, hydro-geochemical processes including weathering, dissolution, mixing, and ion exchange play a vital role in determining the concentration of major and minor ions in groundwater. The present study aimed to evaluate the extent of geogenic contamination in Bikaner city’s groundwater by analyzing several water quality parameters. These parameters included pH, electrical conductivity (EC), total dissolved solids (TDS), bicarbonate (HCO??), phosphate (PO?³?), sulfate (SO?²?), chloride (Cl?), fluoride (F?), sodium (Na?), potassium (K?), calcium (Ca²?), magnesium (Mg²?). The analysis revealed that the groundwater in Bikaner city is significantly affected by the enrichment of certain ions. Specifically, the Piper diagram indicated a predominant presence of calcium (Ca²?) and bicarbonate (HCO??), as well as sodium (Na?) and potassium (K?) coupled with chloride (Cl?). These findings suggest that groundwater, particularly from deep wells, is highly contaminated and unsuitable for drinking or other domestic uses. This contamination is likely influenced by anthropogenic activities, including the discharge of sewage effluents and other pollutants.

Drug Regulatory Affairs (DRA) plays a crucial role in ensuring the safety, efficacy, and quality of pharmaceutical products. It involves navigating complex regulatory requirements set by health authorities such as the FDA, EMA, and WHO to achieve market authorization for drugs. The regulatory landscape is dynamic, with evolving guidelines and standards that govern the clinical trials, manufacturing, marketing, and post-marketing surveillance of drugs. This field is essential in safeguarding public health by ensuring that drugs meet stringent safety and efficacy standards before reaching consumers. DRA professionals bridge the gap between pharmaceutical companies and regulatory bodies, ensuring compliance with national and international regulations while promoting innovation in drug development. As globalization continues to shape the pharmaceutical industry, the importance of harmonizing regulatory standards across regions has become more pronounced, aiming for faster drug approvals and better access to treatments worldwide. The regulatory affairs is an government bodies which is act an regulatory authorities. They work under the government agencies. Drug Regulatory Affairs (DRA) can work an organization of ICH, CDSCO, GLP, GCP, CGMP. Their major work is to control safety, efficacy, quality of the drug and also to control the side effects, errors of the drug. The regulatory authorities is responsible for the approval of new drug. Regulatory affairs professionals is also known as regulatory compliance professionals. In this article we focus regulatory affairs role and regulatory authority. They can provide the drug manufacturing ethics to the production department in pharmaceutical industry. It is a position mostly found within regulated industries, such as pharmaceuticals, medical devices, cosmetics, agrochemicals (plant protection products and fertilizers), energy, banking, telecom etc. Regulatory affairs also has a very specific meaning within the healthcare industries (pharmaceuticals, medical devices, biologics and functional foods). They have an crucial function in industries like pharmaceuticals, biotechnology, and medical devices.

According to ayurveda, the creation of garbha in the garbhashaya, by the permutation of Shukra, Shonita with atma is known as garbha so this process is known as Garbhdharana. Different components originating from Pachamahabhuta takes part in the formation development of the garabha, similarly some components of garbha originate from the parents which are called Matrija & pitrija bhava. Atma and satva also have their roles in development of Foetus. The whole process of development of the foetus from two cell to mature foetus is called Garbhavkranti. The matter related to Garbhavkranti is described in Brihatrayes are Scattered, this matter is collected and compiled for study of foetal development is easier and proper way. In the Ayurvedic literature one finds a good description of month wise foetal development in detail.

The increasing prevalence of skin diseases has led to a growing interest in both allopathic and herbal treatments. Skin conditions similar as eczema, psoriasis, and acne not only affect physical appearance but also significantly impact quality of life. Traditional allopathic medicines have been the dependence of treatment; still, their side effects and the rising costs have urged numerous to explore herbal alternatives. Herbal drugs, deduced from various plants, have been employed for centuries in different societies for their remedial properties. Recent studies punctuate the effectiveness of several herbs, in treating skin diseases like psoriasis, demonstrating their eventuality as feasible druthers.

Background: Nardostachys jatamansi DC is a Himalayan medicinal herb that has been described in various traditional systems of medicine for its use in cancer. In view of its traditional claims, and chemical constituents were evaluated in antioxidant properties. Methods: Petroleum ether (NJPE) and hydro alcoholic (NJHA) roots of N. jatamansi were prepared. Phytochemical investigation and antioxidant activities were determined using suitable methods. Results: NJH fractions exhibited prominent antioxidant activity with significant correlation between phenolic content and ABTS (IC50) scavenging (R = ?0.9988, P < 0.05), and total antioxidant capacity (R = 0.4396, P > 0.05). Statistical analyses revealed NJHA and NJPE exhibited significantly higher (P < 0.05). Cell cycle analysis demonstrated that NJM, NJPE and NJEA caused G2/M arrest while NJDE caused oxidation cells. Conclusion: According to our findings, NJHA has important properties that are mediated via pro-apoptotic and cell cycle disruption. Additionally, this study emphasizes NJHA's antioxidant capacity, which is explained by the phenols it contains. Further mechanistic and phytochemical studies are being conducted to determine the active principles of NJPE, which was shown to be the most powerful fraction..

Seborrhoeic dermatitis (SD) is a common skin disorder marked by erythematous patches with yellow-grey scales. It often affects the face, scalp, upper chest, and back. Seborrhoeic dermatitis of the scalp affects almost half of all adults. Despite its widespread prevalence, the reason has not been fully recognised. Numerous intrinsic and external environmental factors, such as excessive sebum production, fungal colonisation of the skin's surface, genetic predisposition, and dynamics, can all play a role in disease development. According to the Unani system of medicine, this sickness is caused by Akhl??-e-Radiyah (morbid matter). Haz?z/Abria, also known as Bafa, is a chronic scalp condition characterised by the discharge of small scales. It is also attributed to Balgham M?li? (saline phelgm) or Dam-i-Sawd?w? (black bile in blood).

Anemia has emerged as a serious global health concern. Although anemia affects people everywhere, especially developing countries have the highest prevalence of the condition. In order to evaluate the prevalence of anemia among males in the Maskeliya area, the study was planned. The data were collected from the selected laboratories for a period of one year. The relevant parameters to the study title, such as HB, RBC, MCV, and MCHC, were recorded and statistical analysis was performed via SPSS. It showed that 15.36% of anemic males were identified, and it was on a decreasing trend compared to previous years. The 61-70 male age categories have a high anemic prevalence. Among them, 21.9% were found at the mild anemic level, while 2.1% and 1% were found at the moderate and severe anemic levels, respectively. The age categories of 21–30 and 31–40 had the lowest number in all stages of anemia. Tamils were found to have a high (85.4%) prevalence of anemia compared to other ethnic groups, while Muslims were low in prevalence (3.1%). May showed the highest prevalence of anemia among males, while July and October showed the lowest prevalence of anemia. Further, the anemic trend was increasing in pattern from January to May, and from June to December, it was declining. According to the present findings, the anemic males had high, normal, and low levels of RBC, MCV, MCHC, and MCH, and the reason for the differences should be investigated further. The prevalence of anemia was considerable among males in the Maskeliya area, based on investigation reports performed in 2023. There were significant correlations found between the age category, ethnicity, and season.

Wounds remain a huge public health issue, at least in terms of morbidity and long term disability, throughout the world, especially in the developing countries. Plant-derived natural products are significant as sources of medicinal agents and models for the design of new remedies. This study was done to prove the effectiveness of Hyoscyamus niger on the management of wounds through evaluating the wound healing activity of Hyoscyamus niger seed powder on wistar albino rats. Along with that compare the effectiveness of Hyoscyamus niger seed powder between male and female rates based on Unit Healing Time and wound closure rate. Wister albino rats weighing 200-250g used for experimental study. Animals were divided into three groups of each with 6 animals. Each group consists of 3 male and 3 female rats. The animals of group A was left untreated and considered as control. Group B was served as standard and it received cicatrin powder. Group C was considered as test and treated with prepared test drug. The independent t-Test analysis of the wound circumferences of standard and the test drug initially showed a significant value of 0.374 and 0.305 which is much higher than the p-value of 0.05. Whereas the final readings of the wound circumference between the test drug and the standard drug showed a significant value of 0.001 and 0.004. In other words, which indicates that the test drug is much more effective in the treatment of wound healing than that of the standard drug. The present study revealed Hyoscyamus niger seed powder has the significant accelerating wound healing activity in excised wound model in wistar albino rats also readings shows the female rats have higher healing rate than the male rats. The readings of drug effectiveness and Unit Healing Time leads to the conclusion of that, the test drug is more effective for wound healing than stranded .It confirms the potential value of Hyoscyamus niger seed powder to be considered as a natural product for wound healing.